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Patients who eat primarily processed foods, high-calorie drinks, or large meals despite reduced appetite may lose weight initially but plateau because total energy intake remains excessive

Also, every weight loss drug can cause side effects

Reduced intracerebral hemorrhage and Perihematomal edema volumes in diabetics on sulfonylureas

Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, et al

Given that microglial activation is a major contributor to neuroinflammation and neurodegeneration, these findings suggest that vitamin E may be more effective in controlling inflammatory responses in cortical regions rather than deeper brain structures

doi:10.1016/S0022-2275(20)33379-4