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however, such high concentrations of H 2 O 2 are improbable under physiological conditions in vivo because H 2 O 2 is then degraded to oxygen and water by the reaction with catalase, peroxiredoxin (Prx), or GSH peroxidase (GPx) (Figure 1)

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The modification reduces overall positive charge at physiological pH, potentially affecting cellular interactions, membrane permeability, and receptor binding characteristics

The mechanism underlying the accumulation of free radicals caused by UV rays is unclear