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The European Medicines Agency concluded in June 2025 that NAION represents a very rare side effect of semaglutide medications, affecting approximately 1 in 10,000 users

Glucose tolerance and insulin secretion have been investigated in patients with different thyroid status and experimental hypo- and hyperthyroid animal models, but not yielding a consistent explanation, which is likely due to the severity or duration of thyrotoxicosis or hormone treatment

While UK healthcare professionals can, in exceptional circumstances, prescribe unlicensed medicines under the MHRA 'specials' framework, this would rarely be appropriate for ED given the availability of licensed, evidence-based alternatives

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