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Firstly, during pathogen infections and inflammatory responses, cytokines, toll-like receptor (TLR) ligands, and other immune mediators can stimulate self-reactive T cells, potentially triggering autoimmune responses (95)

Mukherjee AA, Kandhare AD, Rojatkar SR, Bodhankar SL (2017) Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations

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The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle