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R., et al

They were designed to be used alongside lifestyle changes like nutrition and physical activitynot as a replacement for them

Obesity and T2DM decrease L cellderived and increase cellderived GLP-1 in rodents and humans (30, 67, 9299)

Called Triple G, retatrutide acts on three hormone receptors: GLP-1, GIP, and glucagon

The subsequent clinical success of engineered dual and triple incretin agonists has fundamentally altered the interpretation of these early findings

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