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Twice-weekly treatment with 3 mg/kg of the PEGylated exenatide NLY01 for 5 months reduced IL-1, TNF-, and C1q secretion by primary mouse microglia exposed to -synuclein preformed fibrils, thereby limiting astrocyte conversion to the neurotoxic A1 phenotype (46)

Dysregulation of autophagy, endolysosomal trafficking, lysosomal function, and mitochondrial integrity not only promotes neuronal dysfunction and death but also contributes to protein aggregation, neuroinflammation, and disease propagation across neural networks

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Now, every 0.1mL (10 units) contains 0.5mg (or 500mcg) of MT2

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