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8.6 Renal Impairment Pharmacokinetic studies of repaglinide were conducted in patients with mild to moderate renal function impairment (CrCl = 40 80 mL/min), and severe renal function impairment (CrCl = 20 40 mL/min)

These side effects can be intense enough for an estimated 10% to 20% of patients to stop using GLP-1s, and they tend to be dose dependent meaning that the higher the dose, the more intense or frequent the side effects can be

J Nutr (2007) 137(11 Suppl):2547S51S

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A study on the permeation enhancement mechanism of TPE formulation was conducted in the TPE formulation study, which successfully led to the FDA-approval of oral octreotide with a formulation containing C8