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2 Likes Kelman January 31, 2026, 11:50pm #33 Beth: Just sharing that after using DSIP after almost a month, I see zero difference to my deep sleep (according to OURA) Most of my doses were 250mcg Absolutely ZERO effect for me either

Yeah, that actually, the reason I mention that is just from the scientific perspective, which is that it helps us understand how a person is losing this weight, even this good weight, if you will, the lean mass potentially on the drug, because it does suggest that its not a direct effect of the drug itself, but rather an artifact

Orforglipron, by contrast, is a small molecule drug and is meant to be taken orally

Jimenez-Vargas, N

Q: Am I a candidate for GLP-1 weight loss medications

And this is also the very reason why weight loss produces dramatic improvements in PCOS symptoms