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ii) macrophages in the TME (tumour-associated macrophages, TAMs) can adopt different activation states that either promote inflammatory responses (M1) or immune suppression (M2), both paradoxically able to enhance tumour growth depending on the physiological context [356,357,358]

The bigger concern for fair-skinned individuals is the source of the peptide itself

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Subsequently, cells were centrifuged at 4 C, 4,000 g for 15 min, then resuspended in cold buffer A (20 mM HEPES-Na + , pH 8.0, 500 mM NaCl, 1 mM TCEP) and sonicated three times for 15 min each

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