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Initial Pharmacological Therapy (2026 Major Update) For most adultsincluding those without established comorbiditiesinitial therapy should include: Modified-release metformin, plus An SGLT-2 inhibitor, primarily for cardiovascular and renal protection as well as glycaemic control

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In her own words, Its the most positive change in my life. (source) Pepper Schwartz Lost 30 Pounds Pepper Schwartz, not diagnosed with Type 2 diabetes, shared that she initiated off-label use of Ozempic in 2022