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Weight loss occurs when you burn more calories than you consume

If a patient cannot maintain hydration for more than 24 hours, our escalation pathway requires an immediate suspension of treatment and a clinical review to protect the biological health of the kidneys

Based on the populations studied in clinical trials to date, retatrutide has been investigated primarily in adults living with obesity defined as a body mass index (BMI) of 30 kg/m or above as well as in those who are overweight (BMI 27 kg/m or above) with at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or dyslipidaemia

Additionally, there had been data showing that mice with GIP receptors knocked out didnt gain as much weight on a high-fat diet, suggesting to the field that blocking GIP could be a way to treat obesity

Tirzepatide amplifies the effectiveness of these dietary choices by improving the metabolic environment in which food is processed

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