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Activated HSCs further engage mechanotransduction pathways, particularly integrin-mediated signaling, which amplify matrix stiffness and reinforce the fibrotic cascade

Because fruit and vegetables are rich in both potassium and precursors to bicarbonate ions, increasing their consumption might help reduce the net acid content of the diet and preserve calcium in bones, which might otherwise be mobilized to maintain normal pH (see the article on Fruit and Vegetables)

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