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PPO mice model was established by feeding with high-fat diet for 16 weeks, and then injected with semaglutide (30 nmol/kg -1 d -1 , sc.) for 22 days before pregnancy

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Mazdutide works through the synergistic activation of GLP-1 and GCG pathways , enabling: Appetite suppression and increased energy expenditure Blood glucose control and fat mobilization Improvement in visceral fat and hepatic fat metabolism By comparison, Semaglutide mainly relies on the GLP-1 pathway for glucose regulation and appetite suppression, with a more focused but relatively narrower metabolic mechanism

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Treatment with N-acetylcysteine should be initiated for all patients above the treatment line in the Rumack-Matthew nomogram

ClinicalTrials.gov registrations: Phase 2 trial NCT04881760