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According to the available references, the therapeutic potential of ADSC-EVs has been demonstrated in ameliorating MI injury by promoting cardiac angiogenesis, inhibiting cardiomyocyte apoptosis, and improving myocardial function [102, 188, 189] (Fig

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The first group was set as control group without any treatment, while mice in the following four groups were injected with complete Freunds adjuvant (20 L) in their right hind ankle joints, for establishing an AIA model

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