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Proper labeling also plays an important role

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doi: 10.3389/fphar.2025.1712903 Received 25 September 2025 Revised 17 November 2025 Accepted 05 December 2025 Published 08 January 2026 Volume 16 - 2025 Edited by Xiufang Huang, Guangzhou University of Chinese Medicine, China Reviewed by Adnan Amin, Yeungnam University, Republic of Korea Hua Yang, China Pharmaceutical University, China Updates Copyright 2026 Ma, Cao, Yang, Zhu, Wang, Liu, Chen, Liu and Zhang

This isoform architecture means that IGF-1 LR3 and MGF, while sharing the same genetic origin, address entirely different aspects of muscle biology: IGF-1 LR3 acts as a potent, IGFBP-resistant, long-duration IGF-1 receptor (IGF-1R) agonist mediating systemic anabolic signalling, while the MGF E-domain (MGF-Ct24E) acts as a locally-produced mechanosensitive signal that activates satellite cell proliferation through a receptor distinct from IGF-1R

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