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It has been well documented that ethanol exposure could disturb iron homeostasis by downregulating hepcidin expression

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While B12 deficiency is rare, some individuals may suffer from chronic health issues or autoimmune conditions, which prevents the body from properly storing or absorbing vitamin B12

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As an important transcription factor, Nrf2 can not only regulate SLC7A11 transcription, but also up-regulate the expression of GSS and GCLC, which are key rate-limiting enzymes for GSH synthesis (Dodson et al., 2019)

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