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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

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mucuso (25, 50, and 100 mg/kg) caused a significant increase [ F (5, 54) = 1,369

However, due to the relatively large size of scFv fragments (27 kDa), avimers (4 kDa) and peptides (850 Da for WYRGRL) are preferred for constructing targeted DMOADs

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