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"Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor"

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Cardiometabolic Parameters and Body Composition Clinical studies report reductions in systolic and diastolic blood pressure and improvements in selected lipid and cardiometabolic markers

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In e and f , these residues are buried, and thus are not visible, while in g , exposure of these residues provides space for the G protein to bind