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Spotlight on Amylin Combination Strategy 22.5% Weight Loss Achieved in Phase 2 Trial "Amylin Combination Therapy to Address Nausea Side Effects Draws Attention" With Roche making a full-fledged entry into the global obesity drug market, which has been dominated by Eli Lilly and Novo Nordisk, signs are emerging of a major shift in the competitive landscape for obesity treatments

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These boil down to: Lack of regulation Cost Not enough robust safety data on long-term effects

Therefore, a cautious evaluation of the selectivity and specificity of any pharmacological compound used to inhibit DPP4 activity is required [28]