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The novel dual GIP and GLP-1 receptor agonist tirzepatide transiently delays gastric emptying similarly to semaglutide

Furthermore, GLP-1 RAs exhibit anti-inflammatory effects, lowering circulating levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6, while promoting anti-inflammatory mediator production [26]

reviews and clinical literature describe this effect, which can, in some patients, be associated with retained gastric contents and delayed emptying

Targeting the gut microbiome to treat the osteoarthritis of obesity