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Freeman, Rush et al

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By 2023, that figure for young adults had risen nearly seven-fold to 60,567 prescriptions per month , a May 2024 study published in JAMA found

It was found that 48-h exposure to rotenone significantly increased Ca 2+ content, indicated by Fluo3(i) fluorescence, and increased ceramide content, decreased cell size measured as FSC, and increased annexin V binding

Other uncommon but serious risks include pancreatitis and gallbladder disease, with gallstones occurring in a small percentage of users during rapid weight loss

Consequently, the conclusions drawn from the TTO analysis should be regarded as low-quality evidence