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Injectable GLP-1 medications can be administered without regard to meals, while oral semaglutide must be taken on an empty stomach with a small amount of water, at least 30 minutes before eating or taking other medicines

1999 Nov;13(6):537-46

doi:10.1001/archfami.6.4.368CrossRefGoogle Scholar Ceranoglu, TA, Wozniak, J, Fried, R, et al

In addition, section 1833(t)(2) of the Act provides that, subject to certain exceptions, the items and services within an APC group cannot be considered comparable regarding the use of resources if the highest cost for an item or service in the group is more than 2 times greater than the lowest cost for an item or service within the same group (referred to as the 2 times rule)

The exact breakeven depends on current promotional pricing and which dose you settle on, but the pattern holds