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TRIUMPH-4 (Phase 3, 68 weeks) 12mg dose: 28.7% weight loss (~71 lbs / 32 kg average) 9mg dose: 26.4% weight loss (~64 lbs / 29 kg average) Patients also saw 76% reduction in knee osteoarthritis pain Blood pressure reduced by 14 mmHg on average Source: ClinicalTrials.gov (TRIUMPH-4, NCT05931367) The TRIUMPH Phase 3 program includes 4 trials studying retatrutide for obesity, type 2 diabetes, and cardiovascular outcomes

Participants had an average A1C reduction of up to 2.0% and lost an average of 36.6 pounds

Individual responses vary, however

Warfarin and Other Anticoagulants Warfarin's narrow therapeutic index makes any absorption change clinically relevant

BPC-157 drives local angiogenesis (new blood vessel formation) through VEGF upregulation (Sikiric et al., Curr Pharm Des, 2018)

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