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Excluding patients with unknown race or ethnicity in the sensitivity analysis produced results consistent with the primary analysis (Additional file 1: Table S15)

The competition was on: Manufacturers raced to secure Health Canada approval so they could begin making generic versions of the drug, driving down the cost and disrupting the stronghold name brands like Wegovy and Ozempic have on the diabetes and weight-loss market

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While current research focuses predominantly on hepatocytes, potential Kupffer cell modulation in NASH-related inflammation and fibrosis warrants further investigation (78)

Note: Researchers exploring melanocortin pathways and behavioral response mechanisms may find value in the PT-141 peptide for research , widely studied for its potential effects on sexual function in pre-clinical settings