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Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity

Put simply, people can cut protein, vitamins, minerals and other essential nutrient intake below adequate levels when they cut calories

It has been described unfavorable cardiovascular effects probably related to the blockade of ischemic preconditioning mentioned before, an endogenous mechanism that protects the heart from ischemic injury associated with hypoglycemic episodes producing electrocardiographic abnormalities and arrhythmias (Marques et al

Past drugs had both modest efficacy (e.g., only 5% body weight loss) and/or serious side effects (e.g., fen-phen was used widely for weight loss in the 90s, but after the discovery that one of the components caused heart valve problems, it was recalled from the market2)

10.1210/er.2012-1042 80

Additional details including the specific GLP-1 drug to be tested, enrollment size, site locations, and eligibility criteria are expected to be released as the trial progresses into the operational phase