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doi: 10.1177/088307380101600501 76 JaekenJVan den BergheG

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For example, a Vitamin B12 deficiency A lack of RBCs means that not enough oxygen reaches the gut

IR increases glucose production in the liver and decreases glucose uptake in the muscles, liver, and adipose tissue

These are most significant in the early weeks of treatment and during dose escalation, and they can be meaningfully amplified by travel-related factors