Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes
The main transporter expressed by oligodendrocytes is GLAST (EAAT1
However, the rates and distances of diffusion can vary widely across the CNS, depending on the concentration and volume of dopamine release, DAT uptake dynamics, the regional specificity of the dopamine receptors, and the volume of extracellular fluid (Sulzer et al., 2016
The lower and upper permissible levels of consumption of these supplementations also need to be considered (Table 5)
Intracellular redox balance was assessed by measuring the ratio between reduced and oxidized glutathione (GSH/GSSG) using the GSH/GSSG-Glo luminescence assay (Promega TM344)
Dosage and concentration play a major role
