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Tendon and ligament injury The most documented use case

But certainly this is something that I learned from my mentor over 10 years ago, which is now ubiquitous

PMID 15650112

Inadequate dietary intake

Even if crystals form, internal motions within the protein can lead to averaged electron density maps, blurring out the finer details and limiting the resolution of the determined structure (Hekstra, 2023)