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One obesity expert previously said semaglutide, originally a type 2 diabetes drug, is a "game-changer." According to the FDA, approximately 70% of American adults are overweight or obese, which is linked with "serious" health issues, like heart disease, stroke, and diabetes

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This is particularly common for people who experience significant nausea at each step-up

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Although it was difficult to determine the role of GLP-1R in either AP or NTS due to the spread of GLP-1RA drugs, a recent study elucidated the separate role of AP GLP-1R neurons and NTS GLP-1R neurons to encode aversion and satiation, respectively [74]

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