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The analysis included eight randomized controlled trials with 2,372 participants (all with BMI 27 kg/m) and found that weight regain was proportional to the amount initially lost.48 On average, participants who had taken liraglutide regained 2.2 kg, while those who had taken semaglutide or tirzepatide regained 9.69 kg after stopping the medication.48 Similarly, a 2025 review in Biomolecules showed that patients treated with GLP-1 or dual GLP-1/GIP agonists experience substantial weight loss (ranging from about 6% to over 20%) but also significant weight regain upon drug discontinuation

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However, significant changes in body composition and muscle recovery typically take three to six months of consistent use and lifestyle alignment

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These include longer recovery with downtime, post-inflammatory hyperpigmentation (especially in darker skin types), infection, scarring, and prolonged erythema

In the JAMA paper, WHO officials highlighted the need for more long-term data on the drugs safety and efficacy, as well as lower prices to expand access