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[23] In one study, when NAC was added to rat bone marrow cultures, significant improvements were seen in the activity of alkaline phosphatase (levels of which increase when bones are growing) and osteoblastic cultures (cells that develop bone), as well as an upregulation of bone-related gene markers such as collagen

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In DENV infections, virus-induced pathogenic antibodies worsen the disease by facilitating viral entry and replication, whereas in SARS-CoV-2 infections, pathogenic antibodies primarily drive disease progression through excessive immune activation (Figure 1