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The base form (crack or freebase) is typically smoked Cocaine is rapidly metabolized in the liver and blood into two primary, inactive metabolites: benzoylecgonine and ecgonine methyl ester (which are targets for drug analysis)

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This is beneficial in multiple ways, namely, monthly dosing after initial titration dosing, even more prolonged receptor activation along with less peaks and troughs in drug levels, which are thought to contribute to side effects