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Circulating levels of IGF-1 and certain IGFBPs are critical for the maintenance of glucose homeostasis (64)

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High NO concentration and pro-inflammatory cytokines, TNF and IL-1 by AFB 1 ingestion (131), can also inhibit mitochondrial ATP production and stimulate cardiomyocytes apoptosis (132)

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has in fact identified the AGEs as a risk factor for insulin resistance independent of over-nutrition in non-obese mice [53], with such insulin resistance that occurred before changes in blood glucose levels