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84 Epigenetic alterations such as histone modifications (e.g., H3K9me3 loss) contribute to the upregulation of inflammatory genes and an imbalance in macrophage polarization, further reinforcing systemic inflammation

Peer review Peer review information Nature Medicine thanks George Bray, Amanda Adler, Victor Volovici and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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