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These changes persisted or were only partially reversible except for the changes caused by empagliflozin and sotagliflozin which showed full reversibility upon discontinuation

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doi: 10.3390/ijms22042110 79 AtriA

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We also demonstrate intramolecular Friedlnder macrocyclization reactionssufficiently mild to be employed on unprotected and in vitro-translated peptidesthat embed a quinoline pharmacophore directly within the peptide backbone