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New England Journal of Medicine, 387(24), 22452257

As you lose weight, your basal metabolic rate decreases because you are carrying less mass

Average weight loss in the SURMOUNT-1 trial was around 20% at higher maintenance doses

The rationale is that two smaller doses produce a more even medication level throughout the week, avoiding the peak-and-trough pattern that creates intense digestive effects early in the week and diminishing effects late in the week

What Are the Pharmacodynamics of Semaglutide

Retatrutide weight loss from Phase 2 and TRIUMPH-4 Retatrutide entered the clinical picture with a Phase 2 trial published in the New England Journal of Medicine