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While no conclusive human risk has been established, UK and EU SmPCs include this as a precaution rather than a contraindication

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Because of these trade-offs, the optimal strategy depends strongly on the specific molecule and manufacturing conditions

Baseline characteristics were sourced from the STEP-8 trial, the only randomized controlled trial directly comparing semaglutide 2.4 mg with liraglutide 3.0 mg in obesity, thereby providing robust and internally consistent data for this head-to-head evaluation

Needles are designed for single use