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Once the molecule is broken down, the body treats it as simple amino acids rather than the functional antioxidant your cells need

Injectable GLP-1 formulations (subcutaneous semaglutide, tirzepatide) do not have this timing issue since they bypass the gastrointestinal tract for absorption

Cancer Res, 49, 62656268

Changes in the erythrocyte antioxidant enzyme system during transdermal estradiol therapy for secondary amenorrhea

This metabolic improvement may explain why some patients notice skin benefits within weeks of starting treatment, before substantial weight reduction has occurred

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