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Following the catabolism of glucose in the cytoplasm as part of glycolysis, the generated pyruvate is transported to the mitochondrial matrix, where it feeds into the TCA, undergoing oxidation to reduce NAD + to NADH, which is the main electron donor of the ETC 87

PMID 27917122

For longer cycles (6+ months), a more extended break of 6-8 weeks might be prudent

2021 Oct 1;63(10):847-851

It doesn't spike cortisol or prolactin like some GHRPs, and its effects on lipid metabolism and body recomposition are clinically validated

In clinical trials, patients treated with Linagliptin demonstrated significant reductions in HbA1c levels compared to placebo