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Gynecomastia, characterized by breast enlargement, occurs in 44% of cirrhosis cases, also due to elevated estrogen levels, and is related to conditions like extreme obesity, hypogonadism, and various adrenal and testicular diseases (88, 89)

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Tirzepatide (Wegovy and Zepbound) is a dual agonist at the GLP-1 and GIP receptors and is administered once weekly

We think thats a signal worth investigating. While efforts to scour the internet for self-reported drug side effects have been ongoing for more than a decade, screening through social media posts at scale remained challenging until the arrival of large language models such as ChatGPT or Gemini

These effects have been confirmed in animal experiments, but not in humans, and the specific mechanism remains unknown