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Those with prediabetes or metabolic syndrome may respond better

Mowrer has a few suggestions for minimizing GI symptoms related to these drugs: Hydrate

A 2023 observational study published in JAMA Ophthalmology suggested a possible association between GLP-1 receptor agonists and non-arteritic anterior ischaemic optic neuropathy (NAION), though this remains under investigation and no definitive causal relationship has been established

Or maybe you just need a push to get going

This tapering approach allows the body to gradually readjust to unmedicated appetite levels, reducing the rebound effect that many people experience with abrupt discontinuation

However, the mechanisms underlying some of these actions remain poorly defined