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As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted

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Cardiovasc Res 36:276281 Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, Komori K, Nakagawa K, Hou X, Nagai Y, Hasegawa M et al (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2

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Numerosos estudios han demostrado que el glutatin es seguro para el uso tpico diario, por lo que no hay motivo de preocupacin con respecto a los efectos secundarios del glutatin