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These symptoms may indicate poor diabetes control, urinary tract infection, or other conditions requiring prompt investigation and treatment

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No formal contraindications derive from human data

These data were further confirmed by the observations that inhibition of DPP-4 through the administration of Sitagliptin to increase the level of biologically active intact GLP-1 significantly attenuated high blood pressure in young pre-hypertensive spontaneously hypertensive rats (SHRs) [36]

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