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The sea horse-shaped hippocampus, the learning and memory center of the brain is highly susceptible to OS and is markedly affected in AD patients

Thus, NGF-FCS2 was selected to engineer the secreted Exe4 in hepatic cells, hereafter referred to as scExe4

There are four phases of first-in-human clinical trials, and the drug candidates are generally approved after the third phase if they are found safe and effective

Clinical trials have demonstrated cardiovascular and renal protection, leading to additional approvals in high-risk populations

Kiernan JA, Rajakumar N

Indirect calorimetry and locomotor activity were continuously monitored using a comprehensive lab animal monitoring system (CLAMS