Neurol ., 243 , 522529
Most published clinical data comes from AOD-9604, not the unmodified fragment
Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation
Always allow vials to come to room temperature before opening to reduce condensation, and avoid repeated freeze-thaw cycles
So I am trying to avoid those shots but I go 4 days without them and despite oral B12, feel my usual symptoms growing worse
B12 and Older Adults While a B12 deficiency isnt as prevalent as something like vitamin D or folate, evidence suggests that 10-15% of people over the age of 60 are low in B12, likely due to loss of a protein called intrinsic factor, which is essential for the body to absorb vitamin B12