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Elimination occurs primarily through proteolytic degradation of the peptide backbone, similar to how the body breaks down naturally occurring proteins

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Effect of food on tablet formulation Administration of 60 mg VYVANSE chewable tablet with food (a high-fat meal) decreases the exposure (C max and AUC inf ) of dextroamphetamine by about 5% to 7%, and prolongs mean T max by approximately 1 hour (from 3.9 hours at fasted state to 4.9 hours)

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Characterization of rod-specific IGF-1R KO mice Wild-type and rod Igf-1r / mouse retina sections were stained with IGF-1R and Cre antibodies

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