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41 Additionally, in retrospective cohort analyses also using the TriNetX database, both Chou et al and Abbass et al found no association between semaglutide use and risk of NAION

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As of the issuance of this order on August 25, 2025, the importation of APIs obtained through biotechnological processes - such as semaglutide and liraglutide - for compounding purposes was restricted to manufacturers whose APIs have been previously reviewed by ANVISA during the products registration process