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Oxidatieve stress speelt een cruciale rol in de verstoring van insulinewerking, waardoor de glucose-opname in cellen vermindert

Targeting the leukemia cell metabolism by the CPTIa inhibition: functional preclinical effects in leukemias

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Moreover, caspases were found not to be recruited in response to multiple proapoptotic stimuli [189]

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Additionally, 2DG also increases oxidative stress and induces autophagy [20], further contributing to its antitumor effects