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Hong MKH, Macintyre G, Wedge DC, Van Loo P, Patel K, Lunke S et al

10.1038/nm.3128 46 KimE

The fluid retention can also increase blood pressure and stress the cardiovascular system

Conclusion Deciding whether to stop taking metformin when you start a GLP-1 medication like Ozempic is a significant clinical decision that should always be made with professional guidance

However in the last years a new mechanism was reported: a significant decrease in incretins production and or action