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Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

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[DOI] [PubMed] [Google Scholar] 7.Veljaa M, Krni , Braja K, Mildner B, Pavi-Sladoljev D, eveljevi-Jaran D et al

Another HH inhibitor, vismodegib, also exhibited inhibitory effects on tumour growth in preclinical models [303]